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Abstract #3330

Improving fMRI acquisition using single-shot EPTI with distortion-free high-SNR high-CNR multi-echo imaging

Fuyixue Wang1,2, Zijing Dong1,2, Jingyuan Chen1,2, Kawin Setsompop3,4, Jonathan R. Polimeni1,2, and Lawrence L. Wald1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States, 4Department of Electrical Engineering, Stanford University, Stanford, CA, United States


This work aims to address the limitations of EPI and improve fMRI acquisition by developing a single-shot EPTI method, to provide fast distortion-free imaging, with significantly improved tSNR, CNR, robustness to motion, reduced signal dropout, and multi-echo capability for denoising/analysis. The single-shot acquisition is enabled by the newly-designed k-t encoding to provide stronger correlation for improved reconstruction. Results show ss-EPTI achieves: i) 30% higher tSNR efficiency than EPI and 70% higher than 3-shot EPTI; ii) 50% higher CNR than EPI (visual-task); iii) distortion-free fMRI with improved robustness to motion; iv) effective signal dropout reduction; and v) effective non-BOLD variation separation.

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