Abstract #3330

Improving fMRI acquisition using single-shot EPTI with distortion-free high-SNR high-CNR multi-echo imaging

Fuyixue Wang^1,2, Zijing Dong^1,2, Jingyuan Chen^1,2, Kawin Setsompop^3,4, Jonathan R. Polimeni^1,2, and Lawrence L. Wald^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Radiology, Stanford University, Stanford, CA, United States, ⁴Department of Electrical Engineering, Stanford University, Stanford, CA, United States

Synopsis

This work aims to address the limitations of EPI and improve fMRI acquisition by developing a single-shot EPTI method, to provide fast distortion-free imaging, with significantly improved tSNR, CNR, robustness to motion, reduced signal dropout, and multi-echo capability for denoising/analysis. The single-shot acquisition is enabled by the newly-designed k-t encoding to provide stronger correlation for improved reconstruction. Results show ss-EPTI achieves: i) 30% higher tSNR efficiency than EPI and 70% higher than 3-shot EPTI; ii) 50% higher CNR than EPI (visual-task); iii) distortion-free fMRI with improved robustness to motion; iv) effective signal dropout reduction; and v) effective non-BOLD variation separation.

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