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Abstract #3331

Optimization of wide-field optical imaging method towards fMRI integration in mice

Wen-Ju Pan1, Yunmiao Wang2, Harrison Watters1, Lisa Meyer-Baese1, Alaina Corrie Smith1, Dieter Jaeger2, and Shella Keilholz1
1Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA, United States, 2Biology, Emory University, Atlanta, GA, United States


We present an optimized wide-field optical imaging method with GEVI in mice to probe the relationship between slow changes in neuronal membrane potential and the BOLD signal in hindpaw stimulation, demonstrate neuronal sub-threshold activity of slow fluctuations could be possibly isolated from hemodynamic signals.

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