Abstract #3331

Optimization of wide-field optical imaging method towards fMRI integration in mice

Wen-Ju Pan¹, Yunmiao Wang², Harrison Watters¹, Lisa Meyer-Baese¹, Alaina Corrie Smith¹, Dieter Jaeger², and Shella Keilholz¹

¹Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, GA, United States, ²Biology, Emory University, Atlanta, GA, United States

Synopsis

We present an optimized wide-field optical imaging method with GEVI in mice to probe the relationship between slow changes in neuronal membrane potential and the BOLD signal in hindpaw stimulation, demonstrate neuronal sub-threshold activity of slow fluctuations could be possibly isolated from hemodynamic signals.

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