Abstract #3332

Mapping cortical-depth dependent responses in human motor cortex using Spin-echo Echo Planar Time-resolved Imaging (SE-EPTI)

Fuyixue Wang^1,2, Zijing Dong^1,2, Lawrence L. Wald^1,2, Jonathan R. Polimeni^1,2, and Kawin Setsompop^3,4

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Radiology, Stanford University, Stanford, CA, United States, ⁴Department of Electrical Engineering, Stanford University, Stanford, CA, United States

Synopsis

This work utilizes our recently developed spin-echo EPTI technique with minimal T2’-contamination and high specificity to map the layer-dependent responses in primary motor cortex at 7T and further investigate the impact of large vessel bias from T2’ contamination. EPTI resolves multi-contrast images across the readout that are free from distortion and blurring, and simultaneously obtains a SE image with pure T2-weighting and multiple asymmetric SE images with various T2’-weightings. The activation of finger-tapping task was studied using SE-EPTI at 0.9-mm isotropic resolution. Improved specificity of layer-dependent responses was observed using pure SE images.

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