Mapping cortical-depth dependent responses in human motor cortex using Spin-echo Echo Planar Time-resolved Imaging (SE-EPTI)
Fuyixue Wang1,2, Zijing Dong1,2, Lawrence L. Wald1,2, Jonathan R. Polimeni1,2, and Kawin Setsompop3,4
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States, 4Department of Electrical Engineering, Stanford University, Stanford, CA, United States
This work utilizes our recently developed spin-echo EPTI technique with minimal T2’-contamination and high specificity to map the layer-dependent responses in primary motor cortex at 7T and further investigate the impact of large vessel bias from T2’ contamination. EPTI resolves multi-contrast images across the readout that are free from distortion and blurring, and simultaneously obtains a SE image with pure T2-weighting and multiple asymmetric SE images with various T2’-weightings. The activation of finger-tapping task was studied using SE-EPTI at 0.9-mm isotropic resolution. Improved specificity of layer-dependent responses was observed using pure SE images.
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