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Abstract #3366

Fat-Compensated T1 Mapping of Non-Alcoholic Fatty Liver Disease with MPRAGE and MP2RAGE

Andrew Duffy1, Andreu Costa2, Sharon Clarke2,3, Ashley Stueck4, Magnus McLeod5, and James Rioux2,3
1Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, 2Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, 3Biomedical Translational Imaging Centre, Nova Scotia Health Authority, Halifax, NS, Canada, 4Pathology, Dalhousie University, Halifax, NS, Canada, 5General Internal Medicine, Dalhousie University, Halifax, NS, Canada

Synopsis

Fat is a confounding factor in the use of T1 measurements as a non-invasive method of assessing non-alcoholic fatty liver disease. A Dixon-based water/fat separation was used to produce T1 maps based on the separated water signal in MPRAGE and MP2RAGE sequences. A correlation inconsistent with biophysical processes was observed between uncorrected MP2RAGE T1 values and fibrosis stage, but using the fat compensated T1 values corrects the correlation. The same effect was seen to a lesser extent with MPRAGE T1 values. Further investigation and validation with a larger cohort may provide a more reliable biomarker of liver fibrosis within NAFLD.

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