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Abstract #3415

Weekly Apparent Diffusion Coefficient Kinetics in HPV-positive Oropharyngeal Cancer Patients Undergoing Definitive Radiation Therapy

Brigid McDonald1, Renjie He1, Yao Ding2, Travis Salzillo2, Jihong Wang2, Clifton Fuller2, and Abdallah Mohamed2
1Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX, United States, 2UT MD Anderson Cancer Center, Houston, TX, United States


In this study, we investigate weekly changes in mean and median apparent diffusion coefficient (ADC) values from diffusion-weighted MRI for HPV+ oropharyngeal cancer patients undergoing definitive radiation therapy (RT). Trends of increasing ADC values in GTV_P and GTV_N were observed with clear separation at each time point between patients with no evidence of disease vs. recurrence at 2 months post-RT. Because of our small sample size (15), a larger cohort is needed for more robust outcome prediction analysis.

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