In this study, we investigate weekly changes in mean and median apparent diffusion coefficient (ADC) values from diffusion-weighted MRI for HPV+ oropharyngeal cancer patients undergoing definitive radiation therapy (RT). Trends of increasing ADC values in GTV_P and GTV_N were observed with clear separation at each time point between patients with no evidence of disease vs. recurrence at 2 months post-RT. Because of our small sample size (15), a larger cohort is needed for more robust outcome prediction analysis.
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