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Abstract #3425

Dynamic Spiral Imaging of Rodent Pulmonary Ventilation using Natural-Abundance Hyperpolarized 129Xe Imaging

Luis Loza1, Tahmina Achekzai1, Stephen Kadlecek1, Hooman Hamedani1, Faraz Amzajerdian1, Mostafa Ismail1, Ian Duncan1, Kai Ruppert1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States


While a hyperpolarized 129Xe MRI-derived fractional ventilation is a valuable metric for assessing lung function, currently implemented schemes use enriched xenon and rely on static images acquired over breath holds to derive FV. In order to probe pulmonary ventilation under more physiologically natural conditions while keeping costs low, we acquired images during continuous controlled breathing in a mechanically ventilated rat using natural-abundance xenon. In addition to FV, we were able to derive the additional physiologically relevant metrics of tidal volume, functional residual capacity, and phase.

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