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Abstract #3488

SuperRes-EPTI: in-vivo mesoscale distortion-free dMRI at 500μm-isotropic resolution using short-TE EPTI with rotating-view super resolution

Zijing Dong1,2, Jonathan R. Polimeni1,2, Lawrence L. Wald1,2, and Fuyixue Wang1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States


To achieve high spatial resolution in-vivo dMRI (mesoscale at isotropic 500μm), we propose a novel SuperRes-EPTI technique that combines our recently developed EPTI technique with a rotating-view super-resolution acquisition and reconstruction. The SuperRes-EPTI can achieve an overall 3.5× SNR gain (SuperRes×EPTI = 2.7×1.3), while providing images completely-free from distortions that allow for improved super-resolution reconstruction and high effective resolution. The SuperRes acquisition scheme was designed to avoid spin-history artifacts, and incorporates rigid motion correction between thick-slice volumes for high motion-robustness. In-vivo distortion-free dMRI data were acquired at 500μm-isotropic resolution at 3T that reveals detailed fibers in gray matter.

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