We perform a thorough comparison of MRF with reference relaxometry approaches on a NIST/ISMRM phantom and a healthy volunteer. In the NIST phantom, relative bias from -4.7% to 27.7% for the NiCl2 vials and from 5.01% to 28% for the MnCl2 vials within a biological relevant T1 and T2 range. In-vivo, MRF has good repeatability (variations <2%) but substantial bias in WM and GM against the reference approach.
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