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Abstract #3493

Simultaneous triglyceride characterization and water T1 estimation in a breath-hold applied to brown adipose tissue using MR fingerprinting

Jason Ostenson1,2, Bruce M. Damon3, and Evan L. Brittain4
1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Stephens Family Clinical Research Institute Carle Foundation Hospital, Urbana, IL, United States, 4Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Multi-parametric fat-water imaging of brown adipose tissue (BAT) is an important tool to study BAT’s composition and metabolism. We propose a single breath-hold MR fingerprinting method to simultaneously estimate the triglyceride number of double bonds (NDB) and number of methylene-interrupted double bonds (NMIDB), as well as water T1. We provide results of simulation, phantom, and example human BAT studies. The proposed method’s NDB and NMIDB estimates strongly correlate with MRS estimates (ρ = 0.998), and the T1 estimates are similar to those from MRS. The NDB, NMIDB, and T1 estimates in/around BAT are similar to those from the literature.

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