Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients suffer from a variety of physical and neurological complaints indicating involvement of the central nervous system including cognitive and memory dysfunction along with a variety of disabling physical symptoms. The hippocampus plays a key role in cognitive function and is altered in neurodegenerative diseases. In this study, we evaluated the volumetric changes in the subfields of the hippocampus in ME/CFS and performed a correlation between hippocampal subfield volumes and clinical measures. Our study showed that hippocampal subfield volumes were lower/higher in ME/CFS patients compared with healthy controls and are also associated with clinical measures
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