Hyperthyroid patients showed structural and functional abnormalities in the hippocampus region of the brain as suggested by neuroimaging studies. However, the extent of structural, functional, and metabolic changes in hyperthyroid patients is still unclear. We examined the regional hippocampal volume and neuro-metabolite changes in hyperthyroid patients using high resolution T1-weighed imaging and 1H MRS techniques. Hyperthyroid patients showed reduced bilateral hippocampal volume and altered metabolic changes, i.e., Glu/tCr, mI/tCr, and NAA/tCr ratios in the hippocampus, compared to healthy controls. These findings provide evidence that hyperthyroidism results in structural and metabolic alterations in the hippocampus region of the brain.
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