In this study, change of susceptibility level in the gray matter nucleus of T2DM patients and their functional connectivity were investigated using quantitative susceptibility mapping (QSM) and fMRI techniques. We found iron deposition decreased in the thalamus and functional connectivity increased between the thalamus and the hippocampus. Susceptibility reduction suggested an involvement of chronic microglia activation in the depletion of iron from oligodendrocytes in this central and integrative brain region. The functional connectivity may indicate a compensatory enhancement. These results remind that the thalamus may play an important role in patients with T2DM.
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