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Abstract #3640

Correlation between Iron Burden and Cognitive Status in Type 2 Diabetes Mellitus Patients Using Quantitative Susceptibility Mapping

Rui Hu1, Yangyingqiu Liu1, Bingbing Gao1, Wei Du1, Weiwei Wang1, Qingwei Song1, Ailian Liu1, and Yanwei Miao1
1Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, China


The relationship between iron accumulation and cognitive decline in T2DM has not been fully revealed and publicized. This research focuses on assessing the global iron content and high iron content levels of the gray nucleus using QSM, and to analyze the correlation between MSV with significant differences and clinical laboratory indicators and cognitive scores in T2DM Patients. Excessive deposition and uneven distribution of iron protein occur in all nuclei in T2DM patients. Iron is important in the pathophysiology of T2DM, especially the MSVhi in the right PUT was significantly negatively correlated with MoCA (r = -0.485, P = 0.004).

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