Hormone replacement therapy (HRT) in menopausal women can reduce troublesome menopause symptoms and prevent cognitive decline. Several structural and volumetric researches reported that localized morphologic changes associated with estrogen meditation. However, it is still unclear how to minimize menopausal symptoms and to protect a woman’s brain from decline. This study investigated the potential effects of HRT on sex hormone level and brain morphology using an optimized voxel-based morphometry (VBM) method.
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