Gray matter difference associated with hormone replacement therapy in menopausal women: a voxel-based morphometry (VBM) study
Tae-Hoon Kim1, Chang-Won Jeong1, ByoungRyun Kim2, Youe Ree Kim3, Chungsub Lee1, Young Hwan Lee3, and Kwon-Ha Yoon3
1Medical Convergence Research Center, Wonkwang University, Iksan, Korea, Republic of, 2Obstetrics and Gynecology, Wonkwang University School of Medicine and Hospital, Iksan, Korea, Republic of, 3Radiology, Wonkwang University School of Medicine and Hospital, Iksan, Korea, Republic of
Hormone replacement therapy (HRT) in menopausal women can reduce troublesome menopause symptoms and prevent cognitive decline. Several structural and volumetric researches reported that localized morphologic changes associated with estrogen meditation. However, it is still unclear how to minimize menopausal symptoms and to protect a woman’s brain from decline. This study investigated the potential effects of HRT on sex hormone level and brain morphology using an optimized voxel-based morphometry (VBM) method.
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