Application of a modified tri-exponential DWI in detecting the change of glymphatic system: a preliminary exploration in gliomas
Mengqiu Cao1, xiaoqing wang2, ke xue3, Yongming Dai3, and Yan Zhou2
1Department of Radiology, Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shangha, shanghai, China, 2Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shangha, shanghai, China, 3MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China, shanghai, China
Spectral analysis using non-negative least squares in a modified tri-exponential muti-b-value diffusion-weighted imaging(DWI) enables estimation of an intermediate component in the diffusion spectrum between parenchymal diffusion and microvascular pseudo-diffusion. Several studies have suggested the intermediate component to be with the glymphatic alterations in different disease state. The aim of this this study aims to investigate whether the modified tri-exponential model are effective in evaluating the grading and IDH-1 gene type of gliomas.
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