Abstract #3752

Application of a modified tri-exponential DWI in detecting the change of glymphatic system: a preliminary exploration in gliomas

Mengqiu Cao¹, xiaoqing wang², ke xue³, Yongming Dai³, and Yan Zhou²

¹Department of Radiology, Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shangha, shanghai, China, ²Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shangha, shanghai, China, ³MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China, shanghai, China

Synopsis

Spectral analysis using non-negative least squares in a modified tri-exponential muti-b-value diffusion-weighted imaging(DWI) enables estimation of an intermediate component in the diffusion spectrum between parenchymal diffusion and microvascular pseudo-diffusion. Several studies have suggested the intermediate component to be with the glymphatic alterations in different disease state. The aim of this this study aims to investigate whether the modified tri-exponential model are effective in evaluating the grading and IDH-1 gene type of gliomas.

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