Abstract #3753

Alterations of the Intranetwork and Internetwork Connectivity of Default Mode Network and Olfactory Network in Patients with COVID-19

Hui Zhang^1,2, Tom Wai-Hin Chung³, Fergus Kai-Chuen Wong⁴, Siddharth Sridhar^3,5,6, Ivan Fan-Ngai Hung^6,7, and Henry Ka-Fung Mak^1,2,8

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Ear, Nose and Throat Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong, ⁵State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, Hong Kong, ⁶Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, Hong Kong, ⁷The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, Hong Kong, ⁸State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong

Synopsis

To identify the functional abnormalities of olfactory network (ON) and default mode network (DMN) in COVID-19 patients, resting state fMRI (rs-fMRI) was applied in this study. Seed-based and ROI × ROI analysis were used to calculate the inter- and intra-network connectivity of DMN and ON. In the results, COVID-19 patients showed higher intranetwork connectivity in DMN and internetwork connectivity between ON and DMN. We postulated that these greater activities compensate for the deficits of olfactory processing and general well-being. In addition, our study suggests rs-fMRI to be a useful biomarker for the evaluation of COVID patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.