Abstract #3753
Alterations of the Intranetwork and Internetwork Connectivity of Default Mode Network and Olfactory Network in Patients with COVID-19
Hui Zhang1,2, Tom Wai-Hin Chung3, Fergus Kai-Chuen Wong4, Siddharth Sridhar3,5,6, Ivan Fan-Ngai Hung6,7, and Henry Ka-Fung Mak1,2,8
1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong, 3Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong, 4Department of Ear, Nose and Throat Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong, 5State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, Hong Kong, 6Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, Hong Kong, 7The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, Hong Kong, 8State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong
Synopsis
To identify the functional abnormalities of olfactory network (ON) and default mode network (DMN) in COVID-19 patients, resting state fMRI (rs-fMRI) was applied in this study. Seed-based and ROI × ROI analysis were used to calculate the inter- and intra-network connectivity of DMN and ON. In the results, COVID-19 patients showed higher intranetwork connectivity in DMN and internetwork connectivity between ON and DMN. We postulated that these greater activities compensate for the deficits of olfactory processing and general well-being. In addition, our study suggests rs-fMRI to be a useful biomarker for the evaluation of COVID patients.
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