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Abstract #3754

Brain Functional Connectome prospectively encodes Distress Symptoms During COVID-19 pandemic

Nanfang Pan1, Song Wang1, Kun Qin1, Yajing Long1, and Qiyong Gong1
1Huaxi MR Research Center, Chengdu, China


In the prospective investigation of public mental health following COVID-19 pandemic, we assessed the psychological status of a general sample. Furthermore, we built a brain-distress construct which mainly contained within- and between-DMN connection patterns, and the left hippocampus emerged as the hub region in distress-related connectome. Based on customized brain connectomes, we may identify individuals who confer high vulnerability to pandemic-induced distress symptoms with well-performing predictive modeling. Our findings may facilitate the understanding of neural correlates underlying distress on the individual macro-scale network level, and the susceptibility markers may serve as targets for prevention and intervention.

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