Abstract #4178

Early Dynamics of Regional Volume and Diffusion Characteristics after Experimental Neonatal Hypoxic Ischemia with Different Damage Outcomes

Po-Yu Chan¹, Chiao-Ching Huang², Chia-Feng Lu¹, Bao-Yu Hsieh³, and Yu-Chieh Jill Kao¹

¹Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ³Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan

Synopsis

To stratify neonates with different outcomes of hypoxic ischemia (HI) within few hours after birth for the subsequent therapeutic hypothermia, the spatiotemporal profile of MR measurements between two severity outcome groups was depicted as early at 6 h after insult. Changes in volumes, ADC and FA values were observed among different brain regions, suggesting different susceptibility of brain regions to HI in the acute phase of HI.

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