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Abstract #4180

Fiber-specific white matter reductions in older adults with metabolic syndrome

Christina Andica1, Koji Kamagata1, Wataru Uchida1, Kaito Takabayashi1, Yuya Saito1, Keigo Shimoji1,2, Hideyoshi Kaga3,4, Yuki Someya3, Yoshifumi Tamura3,4, Ryuzo Kawamori3,4, Hirotaka Watada3,4, Masaaki Hori1,5, and Shigeki Aoki1
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan, 3Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 4Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 5Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan


We performed fixel-based analysis, which implements the Multi-Shell Multi-Tissue Constrained Spherical Deconvolution method, to investigate the effect of metabolic syndrome (MetS) on fiber-specific white matter (WM) integrity and assess its association with MetS-related components or cognitive or motor functions. Our findings provide evidence of WM degeneration, as reflected by reduced microstructural fiber density and macrostructural fiber bundle cross-section, in regions associated with cognitive and motor functions in MetS. We also observed reduced fiber density in the corticospinal tract in preMetS. Finally, our findings clarified visceral fat accumulation, insulin resistance, and arterial stiffness as risk factors for WM alterations in MetS.

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