Abstract #4180

Fiber-specific white matter reductions in older adults with metabolic syndrome

Christina Andica¹, Koji Kamagata¹, Wataru Uchida¹, Kaito Takabayashi¹, Yuya Saito¹, Keigo Shimoji^1,2, Hideyoshi Kaga^3,4, Yuki Someya³, Yoshifumi Tamura^3,4, Ryuzo Kawamori^3,4, Hirotaka Watada^3,4, Masaaki Hori^1,5, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan, ³Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, ⁴Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ⁵Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Synopsis

We performed fixel-based analysis, which implements the Multi-Shell Multi-Tissue Constrained Spherical Deconvolution method, to investigate the effect of metabolic syndrome (MetS) on fiber-specific white matter (WM) integrity and assess its association with MetS-related components or cognitive or motor functions. Our findings provide evidence of WM degeneration, as reflected by reduced microstructural fiber density and macrostructural fiber bundle cross-section, in regions associated with cognitive and motor functions in MetS. We also observed reduced fiber density in the corticospinal tract in preMetS. Finally, our findings clarified visceral fat accumulation, insulin resistance, and arterial stiffness as risk factors for WM alterations in MetS.

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