Abstract #4227

The value of different diffusion models in evaluating liver regeneration after standard partial hepatectomy in rats

caixin Qiu¹, shuangshuang xie¹, yajie Sun², yongquan Yu³, xuyang Wang², jinxia Zhu⁴, Grimm Robert⁵, and wen Shen²

¹Radiology Department, Tianjin First Center Hospital, TIANJIN, China, ²Tianjin First Center Hospital, TIANJIN, China, ³Weihai Central Hospital, SHAN DONG, China, ⁴MR Collaboration, Siemens Healthcare Ltd., BEIJING, China, ⁵MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Different diffusion weighted imaging (DWI) models were used to evaluate microscopic changes of residual liver in rats after standard partial hepatectomy (70%PH). Multiple b-value DWI at multiple timepoints after 70%PH were acquired, and the data was analyzed using three diffusion models: conventional monoexponential DWI, intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) models. Compared with the monoexponential model of DWI, IVIM and DKI models can describe the changes of blood supply in the process of liver regeneration and provide added value in evaluating the microstructure of liver regeneration after standard partial hepatectomy.

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