Vascular invasion has been proved to be closely related to the poor prognosis of rectal cancer. The current gold standard for the diagnosis of rectal cancer vascular tumor thrombus is postoperative pathology. MRI is a common technology in evaluating malignant tumor. In this work, we explored the feasibility of DCE-MRI in quantitatively predicting vascular invasion of rectal cancer. Results showed that the Ktrans and Kep can differentiate the vascular invasion from normal status accurately. Therefore, DCE-MRI may serve as a feasible and non-invasive way in predicting vascular invasion of rectal cancer preoperatively, that is of great significance for clinical diagnosis.