Time-dependent IVIM and non-Gaussian parameters in breast cancer and melanoma xenograft models; correlation with histological markers
Yuko Someya1, Mami Iima1,2, Hirohiko Imai3, Tomomi Nobashi1, Akihiko Yoshizawa4, Masako Kataoka1, Hiroyoshi Isoda1, Denis Le Bihan5,6,7, and Yuji Nakamoto1
1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, Japan, 2Institute for advancement of clinical and translational science, Kyoto University Hospital, Kyoto, Japan, 3Department of Systems science, Graduate School of Informatics, Kyoto University, Kyoto, Japan, 4Department of Diagnostic Pathology, Kyoto University, Kyoto, Japan, 5NeuroSpin/Joliot, CEA-Saclay Center, Paris-Saclay University, Gif-sur-Yvette, France, 6Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 7National Institute for Physiological Sciences, Okazaki, Japan
Time-dependent IVIM and non-Gaussian diffusion parameters might provide additional information over conventional DWI to evaluate features linked to tissue microstructure. Time-dependent IVIM and non-Gaussian diffusion parameters were evaluated both in-vivo and post-mortem in MDA-MB-231 (breast cancer) and B16 (melanoma) models. As expected, fIVIM values significantly dropped from in-vivo to post-mortem conditions with both models at two different diffusion times, confirming the association between fIVIM and tumor perfusion, but did not reach 0, suggesting limitations in the IVIM/non-Gaussian Kurtosis model. ADCo values significantly decreased at long diffusion times and upon sacrification while Kurtosis moderately increased.
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