Abstract #4280

Time-dependent IVIM and non-Gaussian parameters in breast cancer and melanoma xenograft models; correlation with histological markers

Yuko Someya¹, Mami Iima^1,2, Hirohiko Imai³, Tomomi Nobashi¹, Akihiko Yoshizawa⁴, Masako Kataoka¹, Hiroyoshi Isoda¹, Denis Le Bihan^5,6,7, and Yuji Nakamoto¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, Japan, ²Institute for advancement of clinical and translational science, Kyoto University Hospital, Kyoto, Japan, ³Department of Systems science, Graduate School of Informatics, Kyoto University, Kyoto, Japan, ⁴Department of Diagnostic Pathology, Kyoto University, Kyoto, Japan, ⁵NeuroSpin/Joliot, CEA-Saclay Center, Paris-Saclay University, Gif-sur-Yvette, France, ⁶Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁷National Institute for Physiological Sciences, Okazaki, Japan

Synopsis

Time-dependent IVIM and non-Gaussian diffusion parameters might provide additional information over conventional DWI to evaluate features linked to tissue microstructure. Time-dependent IVIM and non-Gaussian diffusion parameters were evaluated both in-vivo and post-mortem in MDA-MB-231 (breast cancer) and B16 (melanoma) models. As expected, f_IVIM values significantly dropped from in-vivo to post-mortem conditions with both models at two different diffusion times, confirming the association between f_IVIM and tumor perfusion, but did not reach 0, suggesting limitations in the IVIM/non-Gaussian Kurtosis model. ADCo values significantly decreased at long diffusion times and upon sacrification while Kurtosis moderately increased.

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