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Abstract #4387

Generation of DSC-MRI derived relative CBV maps from IVIM-MRI data

Lu Wang1, Zhen Xing2, Qinqin Yang1, Congbo Cai1, Zhong Chen1, Dairong Cao2, Zhigang Wu3, and Shuhui Cai1
1Department of Electronic Science, Xiamen University, Xiamen, Fujian, China, 2Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, 3MSC Clinical & Technical Solutions, Philips Healthcare, Shenzhen, China


Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) derived relative cerebral blood volume (rCBV) is a valuable diagnosis biomarker. However, the injection of gadolinium-based contrast agent (GBCA) in DSC-MRI acquisition is prone to cause adverse effects. In this study, a rCBV generation method was proposed based on deep neural network and intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) data. Consistency analysis shows that the rCBV maps generated from our proposed method are of high consistency with the realistic ones, implying that the proposed method has the potential to obtain DSC-MRI derived rCBV maps without GBCA injection.

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