Abstract #4387

Generation of DSC-MRI derived relative CBV maps from IVIM-MRI data

Lu Wang¹, Zhen Xing², Qinqin Yang¹, Congbo Cai¹, Zhong Chen¹, Dairong Cao², Zhigang Wu³, and Shuhui Cai¹

¹Department of Electronic Science, Xiamen University, Xiamen, Fujian, China, ²Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, ³MSC Clinical & Technical Solutions, Philips Healthcare, Shenzhen, China

Synopsis

Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) derived relative cerebral blood volume (rCBV) is a valuable diagnosis biomarker. However, the injection of gadolinium-based contrast agent (GBCA) in DSC-MRI acquisition is prone to cause adverse effects. In this study, a rCBV generation method was proposed based on deep neural network and intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) data. Consistency analysis shows that the rCBV maps generated from our proposed method are of high consistency with the realistic ones, implying that the proposed method has the potential to obtain DSC-MRI derived rCBV maps without GBCA injection.

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