Time-efficient, high resolution 3T whole brain relaxometry using 3D-QALAS with wave-CAIPI readouts
Borjan Gagoski1,2, Jaejin Cho2,3, Zijing Zhang4, Tae Hyung Kim2,3, Wei-Ching Lo5, Daniel Polak6, Marcel Warntjes7, Stephen Cauley2,3, Kawin Setsompop8,9, P. Ellen Grant1,2, and Berkin Bilgic2,3
1Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China, 5Siemens Medical Solutions USA, Inc., Charlestown, MA, United States, 6Siemens Healthcare GmbH, Erlangen, Germany, 7SyntheticMR AB, Linköping, Sweden, 8Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 9Department of Radiology, Stanford University, Stanford, CA, United States
Volumetric, high resolution, quantitative mapping of brain tissues’ relaxation properties is hindered by long acquisition times and signal-to-noise (SNR) challenges. This study, for the first time, combines the time-efficient wave-CAIPI readouts with the 3D-Quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse (3D-QALAS) scheme, enabling full brain quantitative T1, T2 and proton density (PD) maps at 1.15 mm isotropic voxels in only 3 minutes at R=3x2 acceleration. When tested in both the ISMRM/NIST phantom and 7 healthy volunteers, the quantitative maps using the accelerated protocol showed excellent agreement against those obtained from conventional 3D-QALAS at RGRAPPA=2.
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