Abstract #4388

Time-efficient, high resolution 3T whole brain relaxometry using 3D-QALAS with wave-CAIPI readouts

Borjan Gagoski^1,2, Jaejin Cho^2,3, Zijing Zhang⁴, Tae Hyung Kim^2,3, Wei-Ching Lo⁵, Daniel Polak⁶, Marcel Warntjes⁷, Stephen Cauley^2,3, Kawin Setsompop^8,9, P. Ellen Grant^1,2, and Berkin Bilgic^2,3

¹Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China, ⁵Siemens Medical Solutions USA, Inc., Charlestown, MA, United States, ⁶Siemens Healthcare GmbH, Erlangen, Germany, ⁷SyntheticMR AB, Linköping, Sweden, ⁸Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ⁹Department of Radiology, Stanford University, Stanford, CA, United States

Synopsis

Volumetric, high resolution, quantitative mapping of brain tissues’ relaxation properties is hindered by long acquisition times and signal-to-noise (SNR) challenges. This study, for the first time, combines the time-efficient wave-CAIPI readouts with the 3D-Quantification using an interleaved Look-Locker acquisition sequence with T₂ preparation pulse (3D-QALAS) scheme, enabling full brain quantitative T₁, T₂ and proton density (PD) maps at 1.15 mm isotropic voxels in only 3 minutes at R=3x2 acceleration. When tested in both the ISMRM/NIST phantom and 7 healthy volunteers, the quantitative maps using the accelerated protocol showed excellent agreement against those obtained from conventional 3D-QALAS at R_GRAPPA=2.

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