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Abstract #4708

Quantitative magnetic resonance imaging in gadolinium deposition in rat brain

xucong wang1, bing chen2, jian li2, zhen hua wang 1, and Xiaocheng Wei3
1ningxia medical university, yinchuan, China, 2Ningxia Medical University General Hospital, yinchuan, China, 3GE Healthcare, Beijing, China


To investigate the application of quantitative magnetic resonance imaging in the quantitative measurement of gadolinium deposition in the deep cerebellar nucleus (DCN) of rats.The absolute correlation coefficients between DCN T1 value and DCN gadolinium concentration, and DCN/ cerebrar cortex T1WI signal intensity ratio and DCN gadolinium concentration were 0.925 (P<0.001) and 0.849 (P<0.001).These results suggest that quantitative magnetic resonance imaging has a good expression of T1 relaxation time in the dentate nucleus region of cerebellum, which provides a basis for quantitative magnetic resonance estimation of clinical gadolinium deposition.

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