Four-dimensional diffusion-weighted imaging (4D-DWI) attracts lots of attention in MRI-guided radiotherapy since it can provide functional information and better delineate the tumor. However, the previously reported 4D-DW-Propeller-EPI technique used amplitude data binning with continuous interval to sort the blade data that might lead to non-uniform distribution of k-space sampling, therefore being suboptimal for subsequent Propeller-EPI reconstruction. Thus, we propose a new (K-B-optimized) binning method to consider the requirement of propeller reconstruction during the sorting of blade data, thereby improving the k-space distribution. Simulation and in-vivo studies demonstrated that the new binning method can improve the data quality of 4D-DW-Propeller-EPI.
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