Keywords: Small Animals, Spectroscopy
Motivation: Limb amputation frequently leads to pain in residual limb and phantom sensations, but there is no comprehensively described mouse model for translational research.
Goal(s): To extensively phenotype a mouse model of limb amputation to investigate contributing factors of pain.
Approach: Behavioral characterization and multimodal in vivo brain imaging (Voxel-based Morphometry, resting-state functional Magnetic Resonance Imaging and MR-spectroscopy).
Results: VBM showed reduction in primary somatosensory and visual areas (ipsilateral-hemisphere). Functional analysis showed potential neurocompensatory mechanisms and reorganization (left hemisphere). Metabolic data indicated reduced glutamate in the left somatosensory area, and increased N-acetylaspartate in the right somatosensory area.
Impact: We phenotyped a mouse model of limb amputation and showed that sensory and motor areas are involved in the manifestation of pain, which strengthens previous evidence and guides future research.
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