Abstract #0148

Reduced gadolinium dose by an optimized multi-parametric MR-STAT protocol

Fei Xu¹, Edwin Versteeg¹, Hongyan Liu¹, Miha Fuderer¹, Stefano Mandija¹, Oscar van den Heide¹, Vera C. Keil², Anja van der Kolk^3,4, Jan Willem Dankbaar⁵, Sarah M. Jacobs³, Tom J. Snijders⁶, Cornelis A.T. van den Berg¹, and Alessandro Sbrizzi¹

¹Computational Imaging Group for MR diagnostics & therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, ³Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands, ⁵Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, MR-STAT; Contrast Enhancement Imaging

Motivation: Several concerns have been raised about the harmful effects of gadolinium-based contrast agent (GBCA) usage during MRI exams.

Goal(s): To reduce the GBCA dose in MRI protocols.

Approach: We developed an optimized and fast MR-STAT protocol for “pre- and post-injection” quantitative MRI and applied it to two retrospective simulated patient datasets and one prospective in-vivo scan.

Results: The inferred lesion masks generated by comparing “pre- and post-injection” T₁ maps demonstrated that the proposed relaxometry-based method was able to correctly detect the lesions. Furthermore, the performance for the low-dose protocol was comparable to that of the full-dose one.

Impact: The quantification of T1 changes after administering GBCA by using the accelerated MR-STAT protocol potentially enables a substantial reduction in both GBCA dose and acquisition time in clinical protocols.

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