Abstract #0176

Quantitative Placental R2* Mapping on Rhesus Macaques with Thrombotic and Inflammatory Injury Model

Ruo-Yu Liu¹, Logan T. Keding^2,3, Jessica Vazquez^2,3, Jitka Starekova⁴, Ante Zhu^4,5, Ruiming Chen¹, Heather A. Simmons^2,6, Puja Basu², Andres F. Mejia², Aleksandar K. Stanic⁶, Dinesh Shah⁶, Kevin M. Johnson^1,4, Diego Hernando^1,4, Thaddeus G. Golos^2,3,6, and Oliver Wieben^1,4

¹Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Placenta, Quantitative Imaging, R2* mapping, Biomarkers, Contrast Agents, Ferumoxytol

Motivation: Pregnancy complications are often associated with placenta dysfunction, which lacks non-invasive assessment in early pregnancy.

Goal(s): Evaluating placental R2* as a non-invasive and quantitative biomarker to identify and monitor pregnancy complications.

Approach: We introduce a novel thrombotic and inflammatory placental injury model of rhesus macaques and report mean values, histograms, and spatial distribution of placental R2* based on blood oxygenation level dependent (BOLD) MR imaging at different gestational ages before and after iron nanoparticle (ferumoxytol) administration.

Results: Higher overtime and post-contrast increase in mean values and more heterogeneous spatial patterns of R2* are observed in placentas with induced injury.

Impact: A refined nonhuman primate model for thrombosis and inflammation is introduced for investigating placental pathology. Larger R2* increases over time and immediately after ferumoxytol injections suggest the potential for R2* to be an indicator of pathology with or without contrast.

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