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Abstract #0216

Imaging the metabolic profile of the normal appearing brain in patients with brain metastases using hyperpolarized [1-13C]-pyruvate MRI

Nicole I.C. Cappelletto1,2, Hany Soliman3, Nadia D. Bragagnolo2, Biranavan Uthayakumar1,2, Arjun Sahgal3, Albert P. Chen4, Ruby Endre2, Nathan Ma5, William J. Perks5, Jay S. Detsky3, Chris Heyn6, and Charles H. Cunningham1,2
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4GE Healthcare, Toronto, ON, Canada, 5Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Metabolism, Cancer, Brain

Motivation: The metabolic profile of normal appearing brain tissue in patients with brain metastases may be related to the course of disease.

Goal(s): To test whether patients with brain metastases exhibit differential metabolism in normal appearing brain parenchyma compared to healthy control participants.

Approach: Hyperpolarized [1-13C]-pyruvate and T1w MRI were used to compare the metabolism and volumes of normal appearing brain regions in patients and healthy control participants.

Results: The lactate-to-bicarbonate (p=0.0004) and lactate-to-pyruvate (p=0.04) ratios were significantly increased in the normal appearing brain parenchyma of patients compared to controls.

Impact: The metabolic profile of normal appearing brain parenchyma in patients with brain metastases exhibits significantly increased glycolytic metabolism compared to healthy control brains when imaged using hyperpolarized [1-13C]-pyruvate MRI and may be related to the course of disease.

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Abstract

Keywords