Keywords: Spectroscopy, High-Field MRI, downfield, Spectral editing, MRSI
Motivation: Integration of downfield, upfield, and spectral editing MRSI in clinical studies
Goal(s): Generate high resolution downfield (0.37 ml) and upfield (0.2 ml) in vivo MRSI at 7T
Approach: CHEAP-ESPI and SLOW-EPSI were used for downfield and upfield (spectral editing) MRSI, respectively, in two healthy volunteers and one glioma patient.
Results: A 4-minute acquisition with CHEAP-EPSI suffices for downfield MRSI (ATP/GSH+ and NAA+), while a 9-minute acquisition with SLOW-EPSI is adequate for upfield (NAA) and spectral editing (2HG, GABA, and Glx) MRSI.
Impact: The combination of CHEAP-EPSI and SLOW-EPSI enables the measurement of downfield, upfield, and edited 3D MRSI within approximately 13 minutes, making it readily integrable into clinical routine examinations or scientific studies.
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