Abstract #0257

Selective measurement of glycine in human brain by optimal control method at 7 T

Ying Liu¹, Jiaxiang Xin², Yifan Yuan³, Caixia Fu⁴, Ying-Hua Chu², Da-Xiu Wei⁵, Ye-Feng Yao⁵, and He Wang¹

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²MR Research Collaboration Team, Siemens Healthineers Ltd, Shanghai, China, ³Huashan Hospital, Fudan University, Shanghai, China, ⁴MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, ⁵Physics Department and Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China

Synopsis

Keywords: Pulse Sequence Design, Spectroscopy

Motivation: Glycine is key neurotransmitter associated with the the pathogenesis and imaging of gliomas, yet the non-invasive quantification of it remains a challenge.

Goal(s): To selectively measure glycine in human brain.

Approach: A new pulse sequence was developed, utilizing optimal control techniques to selectively detect glycine signals while effectively suppressing myo-inositol signals.

Results: Experimental results from both phantom models and glioma patient studies confirm the selective detection of glycine. Preliminary data indicate a relationship between glycine signal intensities and glioma distributions.

Impact: The use of the developed pulse sequence for the selective measurement of glycine in the human brain may provide possibility for more accurate assessment of glioma aggressiveness.

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