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Abstract #0296

Comparison of MR-Signal-based and Deformation-based Ventilation Measurement in Pediatric Patients with non-CF Bronchiectasis

Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Filip Klimeš1,2, Robin Müller1,2, Marius Wernz1,2, Martha Dohna1, Diane Renz1, Frank Wacker1,2, and Jens Vogel-Claussen1,2
1Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany

Synopsis

Keywords: Lung, Lung, Registration, Ventilation, Free-Breathing

Motivation: A previous study showed that MR-signal-based (RVent) and deformation-based approaches (JVent) for ventilation are theoretically equivalent, but result in different defects in a digital lung model. A verification of this finding using real data is pending.

Goal(s): Test if both ventilation parameters result in significant differences on a global and regional level.

Approach: A retrospective analysis of 32 patients with non-CF Bronchiectasis was performed, calculating RVent, JVent and corresponding ventilation defects for three registration variants.

Results: There were significant differences and patterns on a global and regional level, which are consistent with the findings in the lung model study.

Impact: Inferior-superior gradient in deformation-based ventilation measurements might lead to a biased defect detection. Therefore, use of such parameters might require further correction and/or diligent registration optimization. Thus, signal-based ventilation with more stable performance across different registration variants might be benefical.

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