Keywords: Tumors (Post-Treatment), Tumor, glioma, neuro-oncology
Motivation: SOX2 is a marker of pluripotency that highlights tumor invasion beyond gross histological signatures, but the imaging characteristics of pluripotent tumor areas are unknown.
Goal(s): Do conventional imaging signatures deliniate SOX2 positive staining tumor cell regions?
Approach: This study compared imaging data from 22 glioma patients to aligned SOX2 autopsy tissue samples.
Results: SOX2-positive regions were often present beyond the imaging-defined tumor mass, with a positive but not collinear association between SOX2 and cell density across most. However, MR intensity distributions did not effectively distinguish SOX2 positivity.
Impact: These results highlight a novel signature of tumor presence that exists well-beyond the imaging-defined margin and is not readily detectable via conventional imaging. These areas are spared treatment and require new technological developments to detect non-invasively.
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