Abstract #0579

Multinuclear fingerprinting (MNF): high-resolution simultaneous proton/sodium MR fingerprinting

Gonzalo Gabriel Rodriguez^1,2, Lauren O’Donnell², Zidan Yu^3,4, Martijn Cloos⁵, and Guillaume Madelin²

¹NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, ²Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, NYU Langone Health, New York, NY, United States, ⁴Departement of Medicine, University of Hawaii, Honolulu, HI, United States, ⁵Centre for Advanced Imaging, The University of Queensland, Brisbane, Brisbane, Australia

Synopsis

Keywords: MR Fingerprinting, Brain, 23Na, 1H

Motivation: Develop a method for high-resolution multinuclear fingerprinting (MNF).

Goal(s): Generate high-resolution multi-parametric maps of proton and sodium nuclei.

Approach: The method consists of two steps:
1- Simultaneous acquisition of ¹H/²³Na MR fingerprinting (MRF) data resulting in high-resolution ¹H maps and low-resolution ²³Na maps
2- Application of a super-resolution algorithm to match the in-plane resolution of ²³Na maps to the in-plane high-resolution of the ¹H maps.

Results: Multinuclear fingerprinting (MNF) can generate high-resolution ¹H density, T₁, and T₂ maps and ²³Na density, T₁, T_2long, and T_2short maps in brain from simultaneous ¹H/²³Na MRF data acquired at 7 T in 21 min.

Impact: This method provides a novel approach towards the investigation of sodium maps as biomarkers for neurological diseases.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.