Abstract #0596

High-Resolution MR Microscopy of Mouse Spinal Cord at 15.2 T

Bibek Dhakal^1,2, Benjamin M. Hardy^1,2, Adam W. Anderson^2,3,4, Mark D. Does^2,3,4, Junzhong Xu^1,2,3,4, and John C. Gore^1,2,3,4

¹Department of Physics, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁴Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Microstructure, Microstructure, MR microscopy, Diffusion MR microscopy, Micro-solenoid RF coils, Ultra-high field strength, Mouse spinal cord

Motivation: The research aims to overcome the challenges of performing microscopy to assess the microstructure of mouse spinal cords at high spatial resolution.

Goal(s): Our goal is to develop a micro-solenoid radiofrequency circuit, which combined with ultra-high field strength and fast imaging sequences, including diffusion MRI, can achieve microscopic-resolution images.

Approach: The study involves the development of a micro-solenoid transceiver coil, and imaging at 15.2 T using fast diffusion imaging sequences to achieve images of excised specimens at microscopic resolution.

Results: The micro-solenoid radiofrequency circuit significantly improved SNR, enabling high-resolution imaging and accurate data sets for implementing diffusion models at micron-scale resolution.

Impact: High-resolution diffusion imaging may provide estimates of diffusion parameters at a scale more commensurate with the microstructure of the spinal cord than in vivo acquisitions. This will be useful for validating models of water diffusion in complex environments neuronal tissue.

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