Abstract #0688

Non-invasive quantification of myocardial volume oxygen consumption using free-breathing, ungated, self-calibrated MR blood oximetry

Chia-Chi Yang¹, Archana Malagi¹, Yuheng Huang^2,3, Ghazal Yoosefian², Xinheng Zhang^2,3, Xinming Guan², Anthony Christodoulou^1,4, Debiao Li¹, Hui Han⁵, Rohan Dharmakumar², and Hsin-Jung Yang¹

¹Biomedical Imaging Research Institude, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²krannert cardiovascular research center, Indiana University School of Medicine, Indianapolis, IN, United States, ³Bioengineering, UCLA, Los Angeles, CA, United States, ⁴Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, ⁵Radiology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Heart Failure, Heart, myocardial volume oxygenation consumption

Motivation: Whole-heart myocardial oxygen consumption (MVO₂) is the central factor that determines cardiac function and is a sign of heart diseases.

Goal(s): We proposed a high-resolution, free breathing, cardiac-phase resolved sequence to quantify MVO₂ in the beating hearts.

Approach: Healthy pigs were scanned at 3T. Coronary sinus images were acquired with a continuous, free-breathing, Radial T2Prep-IR sequence with flow compensation and water excitation and a 2D phase contrast sequence to quantify the MVO₂. Invasive ground truth was also measured to verify the accuracy of our estimation.

Results: The proposed method measured comparable SbO₂,OEF,MBF and MVO₂values to the invasive ground truth.

Impact: The proposed free-breathing, motion-resolved cardiac MR Oximetry technique has the potential to non-invasively measure accurate myocardial oxygen consumption without using ionizing radiation and exogenous contrast agents.

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