Keywords: Digestive, Infectious disease
Motivation: Neural alterations affect intestinal conditions. However, these neural alterations and their potential formation mechanisms remain unclear.
Goal(s): We integrated brain radiomics, the fecal microbiome, and blood metabolomics to investigate neural characteristics in patients with Crohn’s disease (CD) by establishing putative links between the gut microbiota, blood metabolites, and brain alterations.
Approach: Multiomics data were compared between CD patients and healthy controls.
Results: We developed a novel multiparameter brain MRI-based radiomics model to characterize the neural features of CD patients. Causal mediation analysis revealed significant pathways supporting the pivotal role of the gut-brain axis in neural alterations in CD patients.
Impact: We developed a novel multiparameter MRI-based radiomics model to comprehensively characterize neural alterations in patients with Crohn’s disease. We presented biologically plausible evidence of the formation mechanism underlying these alterations from a gut-microbiota-brain axis perspective.
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