Abstract #0747

Longitudinal Changes of BBB Permeability and transcytolemmal permeability in Alzheimer’s Disease Mice: A Non-Contrast MRI Study

Chuhan Xiong¹, Yu Yin², Qinfeng Zhu¹, Ruicheng Ba¹, Zhecheng Jin¹, Zhiliang Wei³, Zixuan Lin¹, and Dan Wu¹

¹College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Chemistry, Zhejiang University, Hangzhou, China, ³Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: BBB disruption is demonstrated in Alzheimer’s disease (AD) but how does it change during the progression of disease, and its relationship with transcytolemmal water exchange are not clear.

Goal(s): We aimed to evaluate the longitudinal changes of water exchange across BBB and across cytomembrane in AD mice.

Approach: BBB permeability and transcytolemmal permeability to water were assessed in 3xTg-AD mouse from 6 to 10 months of age using WEPCAST and tDKI MRI, respectively.

Results: Elevation of BBB permeability in AD mice started as early as 6 months. Transcytolemmal permeability was found to increase in the hippocampus.

Impact: Current results suggested the potential role of BBB and transcytolemmal permeability as a biomarker in the early detection of AD. Their co-increase may be related to the altered glymphatic function.

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