Keywords: Liver, Quantitative Imaging, free-breathing liver R2∗ mapping;hepatic iron overload
Motivation: Existing liver iron quantification methods are inadequate for extreme iron deposition, hindering effective guidance for iron chelation therapy.
Goal(s): Evaluate the practicality of a free-breathing, single-echo UTE sequence with varying echo times for multiple acquisitions in assessing severe hepatic iron overload.
Approach: A 3.0T UTE sequence with rigid-based motion correction was used to assess hepatic R2* in nine thalassemia patients, and compared with LIC from Ferriscan and R2* from a 1.5T GRE sequence.
Results: UTE-R2* correlated well with GRE-R2* and Ferriscan-LIC, and could differ hepatic iron content in patients whose Ferriscan-LIC or GRE-R2* reach to upper limit.
Impact: An imaging strategy utilizing a free-breathing, single-echo UTE sequence with variable echo times for multiple acquisitions, combined with rigid-based motion correction, could be employed to evaluate extreme hepatic iron deposition.
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