Keywords: Neurofluids, Neurofluids
Motivation: Vasomotion has been hypothesized as a mechanism for brain paravascular clearance, which could be impaired in multiple neurodegenerative conditions.
Goal(s): To measure vasomotion in vivo in human brains using MRI.
Approach: A single-shot T1-weighted Cine-FLASH sequence was optimized to provide high temporal resolution in two adults, as well as during a visual stimulation paradigm in one. We performed a Fourier decomposition of the signal in brain vascular structures.
Results: An ultra-low-frequency signal was observed consistent with vasomotion in posterior cerebral arteries while no such signal could be identified in the parenchyma. A substantial amplification of this signal could be observed during visual stimulation.
Impact: This method could help studying brain waste clearance and its dysfunction in humans in vivo.
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