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Abstract #1105

Aberrant activations associated with developmental dyslexia and READ1 deletion induced by visual/attentive tasks

Alice Giubergia1,2, Sara Mascheretti3,4, Filippo Arrigoni5, Alessio Toraldo3,6, Chiara Andreola7, Martina Villa8,9,10, Valentina Lampis3,4, Roberto Giorda11, Marco Villa11, and Denis Peruzzo1
1Neuroimaging Unit, IRCCS "Eugenio Medea", Bosisio Parini (LC), Italy, 2Department of Information Engineering, University of Padova, Padova, Italy, 3Department of Brain and Behavioral Sciences, University of Pavia, Pavia (PV), Italy, 4Child Psychopathology Unit, IRCCS "Eugenio Medea", Bosisio Parini (LC), Italy, 5V. Buzzi Children’s Hospital, Milano (MI), Italy, 6Milan Centre for Neuroscience (NeuroMI), Milano (MI), Italy, 7Laboratoire de Psychologie de Développement et de l’Éducation de l’Enfant (LaPsyDÉ), Université Paris Cité, Paris, France, 8Department of Psychological Sciences, University of Connecticut, Storrs, CT, United States, 9The Connecticut Institute for Brain and Cognitive Sciences, University of Connecticut, Storrs, CT, United States, 10Yale Child Study Center Language Sciences Consortium, New Haven, CT, United States, 11Molecular Biology Laboratory, IRCCS "Eugenio Medea", Bosisio Parini (LC), Italy

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based)

Motivation: Developmental Dyslexia (DD) is a complex and heritable neurodevelopmental disorder with heterogeneous genotype-phenotype pathways.

Goal(s): Utilise fMRI as a bridge between genetic factors (DD-candidate risk genes) and behavioral traits (proficiency in reading skills).

Approach: A GLM was used to test for relationships between reading proficiency, genetic mutation, and neural activations of two visual-attentive tasks.

Results: A genetic vulnerability to alterations in neural activation was found in the ventral attentive and salient networks during reading-related stimuli in subjects with poor reading proficiency.

Impact: Functional MRI has shown to be a valuable mediator linking genotype to phenotype, possibly leading to the optimization of criteria to diagnose Developmental Dyslexia and the early identification of children with a genetically driven susceptibility.

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Abstract

Keywords