Keywords: Functional Connectivity, Brain Connectivity, Dyslexia, Dynamic Causal Modeling
Motivation: Alterations in functional connectivity between regions involved in reading and visuo-attention networks have been associated with developmental dyslexia. However, the causal relationship between regional activity remains unknown.
Goal(s): We aimed to investigate the causal relationship between regions of the visuo-attention network in developmental dyslexia and typical readers during a coherent motion detection task.
Approach: Using Dynamic Causal Modeling, the causal connectivity between regions in the cortex and cerebellum was estimated to understand aberrant network function.
Results: Children with developmental dyslexia showed remarkable differences in patterns of excitatory and inhibitory communication between cerebellum and visuo-attention regions compared to typical reader children.
Impact: Dynamic Causal Modeling can evaluate cortico-cerebellar causal relationship (i.e., effective connectivity) in healthy subjects and in neurodevelopmental conditions such as developmental dyslexia. New evidence points toward a critical role of the cerebellum in reading impairment, with potential consequences for intervention.
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