Abstract #1107

Aberrant brain structural–functional connectivity coupling related to cognitive impairment in different cerebral small vessel disease burden

Xinyue Zhang¹, Changhu Liang¹, Mengmeng Feng², Haotian Xin², Yian Gao¹, Chaofan Sui¹, Na Wang¹, Nan Zhang¹, Hongwei Wen³, and Lingfei Guo¹

¹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Department of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, ³School of Psychology, Southwest University, Chongqing, China

Synopsis

Keywords: Functional Connectivity, Aging

Motivation: The impact of different cerebral small vessel disease (CSVD) burden on brain structural and functional connectivity coupling and their correlation with neurocognitive outcomes remain largely unknown.

Goal(s): To explore the alterations of structural and functional connection network (SC-FC) coupling in the whole brain and different functional modules of patients with different CSVD burden compared with healthy controls.

Approach: Diffusion tensor imaging (DTI) and Resting-state blood-oxygen-level-dependent (BOLD) fMRI techniques were used to analyze structural and functional brain connections.

Results: Severe CSVD burden patients exhibited significantly decreased whole-brain SC-FC coupling, reduced modular SC-FC coupling and associated with impairment of cognitive outcomes.

Impact: SC-FC coupling might provide a more sensitive neuroimaging biomarker of CSVD burden as well as new insights into the pathophysiologic mechanisms of the clinical development of CSVD.

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