Keywords: fMRI Analysis, fMRI (resting state), Laminar connectivity, depression
Motivation: A previous own study in healthy volunteers indicated that global laminar connectivity is highly dynamic, suggesting that it could be sensitive to altered brain conditions.
Goal(s): Does global laminar connectivity change in depression?
Approach: We acquired high-resolution fMRI data from patients before and after treatment and conducted a dynamic connectivity analysis focused on cortical depth.
Results: The prevalence of the depth-connectivity states co-evolved with the psychometric scores of patients.
Impact: The presented results may motivate other researchers working on laminar fMRI to average across ROIs and evaluate the effect of diverse brain conditions on the global component of depth-dependent connectivity, whose potential relevance is suggested by our preliminary studies.
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