Keywords: Large Animals, Nonhuman Primates, Susceptibility, Marmoset, Nonhuman primate, QSM, R2*, SWI, 9.4T, High-field
Motivation: Quantitative Susceptibility Mapping (QSM) is still not widely employed in non-human primates (NHP). Although it has been recently applied to cynomolgus and rhesus macaques, little attention has been given to other NHPs like marmosets.
Goal(s): Our goal was to establish QSM in marmosets at 9.4 T.
Approach: We conducted high-field MRI on 33 healthy marmosets to achieve superior spatial resolution and sensitivity. We evaluated the contrast-to-noise ratio in the QSM map for four subcortical structures and generated cortex intensity profiles.
Results: In the marmoset brain, QSM provided excellent contrast of subcortical structure, various white matter tracts, and the cortex.
Impact: Establishing QSM in marmosets may be helpful to those interested in comprehending brain tissue structure and organization, refining brain parcellation, and facilitating procedures like MRI-guided stereotactic surgery, injections, and precise neuronal targeting.
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