Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound, MRgFUS, neuromodulation, essential tremor, thermometry
Motivation: Transcranial Ultrasound Stimulation (TUS) is a non-invasive technology for brain stimulation, particularly suited for the neuromodulation of deep brain structures.
Goal(s): We investigated the behavioral effects of low-energy TUS in the thalamus in Essential Tremor patients scheduled for MR-guided ultrasound treatment.
Approach: Two targets were tested: the ventral intermediate nucleus of the thalamus (VIM) and the dentato-rubro-thalamic tract (DRT). MRI was used for procedure guidance and monitoring. The effect was recorded using MR-compatible accelerometers.
Results: VIM low-energy neuromodulation induced transient change in tremor power (p-value< 0.001). DRT neuromodulation reduced tremor power (p-value<0.001) with a sustained post-effect, without MR-thermometry exhibiting any significant thermal rise.
Impact: High precision focusing enhanced by state of the art transcranial aberration correction allowed unprecedent transient tremor reduction in Essential Tremor patients following low-energy thalamic ultrasound stimulation under MRI guidance.
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