Abstract #1284

Low-intensity focused ultrasound with continuous theta burst stimulation induces human primary motor cortex functional connectivity changes

Wei-Chih Yang¹, Kai-Hsiang Stanley Chen², Yih-Chih Jacinta Kuo², Yan-Siou Dong², Gin-Shin Chen³, and Yao-Chia Shih¹

¹Graduate Institute of Medicine, Yuan Ze University, Taoyuan City, Taiwan, ²Department of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan, ³Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan

Synopsis

Keywords: Other Interventional, fMRI (resting state)

Motivation: Combining low-intensity transcranial focused ultrasound stimulation (TUS) akin to continuous theta burst stimulation (cTBS) setting (ctbTUS) with cTBS over M1 can be a potential strengthening non-invasive neuromodulatory method.

Goal(s): To understand the neuroplasticity in response to ctbTUS or simultaneous ctbTUS+cTBS.

Approach: Resting-state fMRI with seed-based analysis with seeds of M1 and its first dorsal interosseous (FDI) muscle representation (M1_FDI) was used to assess functional connectivity (FC) changes due to cTBS, ctbTUS, or ctbTUS+cTBS.

Results: We replicated M1-FC degradations in ipsilateral sensorimotor regions due to cTBS, and verified the potential synergic effect of ctbTUS+cTBS on M1-FC decreases in supplementary motor area.

Impact: Our study is the first to use resting-state fMRI to investigate FC changes within motor network due to either cTBS, ctbTUS, or ctbTUS+cTBS stimulations on left M1. The results help understand the potential of ctbTUS+cTBS to be a novel therapy.

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