Keywords: Blood Vessels, CEST & MT
Motivation: Exploring the CSVD imaging markers can provide insights into the pathophysiology of CSVD, which is crucial for understanding its etiology, development, and clinical interventions.
Goal(s): To investigate potential variations in hippocampal APT values among individuals with CSVD imaging markers and varying degrees of CSVD total burden.
Approach: All the participants conducted the cognitive assessment and the MRI scans. And statistical analysis was used for evaluation.
Results: The hippocampal APT values among different CSVD total load groups were significantly different (p<0.001). The mediation models demonstrated that the APT values of the hippocampus partially mediated the association between CSVD total load and MoCA score.
Impact: Hippocampal APT values may serve as a biomarker for the early detection of neurodegeneration in CSVD patients.
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