Abstract #1360

Importance of Prostatic Fluid on the Apparent Diffusion Coefficient: An IR-Prepared Diffusion-Weighted Investigation of Healthy Prostates

Dominika Skwierawska ¹, Sebastian Bickelhaupt¹, Maximilian Bachl¹, Rolf Janka¹, Martina Murr^1,2, Felix Gloger¹, Tristan Anselm Kuder^3,4, Dominique Hadler¹, Michael Uder¹, and Frederik Laun¹

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ²Section for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Tübingen, Germany, ³Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany

Synopsis

Keywords: Diffusion Modeling, Quantitative Imaging, Signal Modeling, Inversion Recovery, Data Analysis, Contrast Mechanisms, Cancer

Motivation: The apparent diffusion coefficient (ADC) of prostate tissue is generally higher than that of prostate cancer. We hypothesized that the presence of prostatic fluid is partly responsible for the higher ADC.

Goal(s): To elucidate the value of this hypothesis with diffusion-T₁-relaxation experiments.

Approach: Diffusion-weighted data of ten healthy participants’ prostates were sampled with a range of IR times and fitted to a two-compartment model (tissue & fluid).

Results: The ADC(TI) dependency was characteristic of the two-compartment model. ADC(TI) increased with TI from 0 to roughly 1,200 ms, then flipped to smaller ADC values and then approached an asymptotic value at large TI.

Impact: This study contributes to a better understanding of prostate DWI contrast. The observed ADC(TI) dependence may be exploited for improved DWI-based prostate cancer diagnostics.

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